Track insider buy and sell

CEO

100

$5.36

$536.00

161,141

-10.45%

P

2013-03-27

2013-03-28 09:24:50

director officer (CEO)

50

$5.34

$267.00

161,041

-10.11%

P

2013-03-27

2013-03-28 09:24:50

CEO

500

$5.31

$2,655.00

160,991

-9.60%

P

2013-02-27

2013-02-28 17:46:06

CEO

227

$2.75

$624.25

160,491

96.00%

P

2013-02-27

2013-02-28 17:46:06

CEO

535

$2.72

$1,455.20

160,264

98.16%

P

2013-02-27

2013-02-28 17:46:06

CEO

500

$2.71

$1,355.00

159,729

98.89%

P

2013-01-22

2013-01-23 10:00:46

CEO

315

$2.83

$891.45

159,229

-2.83%

P

2013-01-22

2013-01-23 10:00:46

CEO

900

$2.82

$2,538.00

158,914

-2.48%

P

2012-12-26

2012-12-26 13:06:00

CEO

1,142

$3.01

$3,437.42

158,014

-3.32%

P

2012-11-28

2012-11-30 12:07:56

director officer (CEO)

7

$2.14

$14.98

156,872

29.44%

P

2012-11-28

2012-11-30 12:07:56

CEO

1,000

$2.13

$2,130.00

156,865

30.05%

P

2012-11-28

2012-11-30 12:07:56

CEO

100

$2.13

$213.00

155,865

30.05%

P

2012-11-28

2012-11-30 12:07:56

CEO

100

$2.13

$212.60

155,765

30.29%

P

2012-11-28

2012-11-30 12:07:56

CEO

100

$2.12

$212.00

155,665

30.66%

P

2012-11-28

2012-11-30 12:07:56

CEO

300

$2.12

$636.00

155,565

30.66%

P

2012-11-16

2012-11-19 13:50:42

CEO

49,793

$1.82

$90,722.80

143,465

25.69%

P

2012-11-15

2012-11-16 13:55:33

CEO

48,833

$1.69

$82,332.40

93,672

35.82%

P

2012-10-24

2012-10-25 11:34:39

CEO

1,162

$2.95

$3,433.71

44,839

-21.15%

P

2012-08-22

2012-08-23 09:44:53

CEO

815

$4.23

$3,450.71

42,641

-21.11%

P

2012-07-25

2012-07-26 11:43:26

CEO

346

$10.04

$3,472.80

41,826

-57.26%

S

2012-07-02

2012-07-03 13:20:15

officer (Senior VP Medical Affairs)

1,000

$9.79

$9,790.00

35,050

52.81%

P

2012-05-23

2012-05-24 12:39:19

CEO

445

$7.81

$3,475.45

41,105

12.29%

S

2012-05-01

2012-05-03 11:26:17

officer (Senior VP Medical Affairs)

1,000

$10.93

$10,927.00

38,383

24.87%

P

2012-04-25

2012-04-27 09:24:18

CEO

100

$9.92

$992.00

40,660

-14.82%

P

2012-04-25

2012-04-27 09:24:18

CEO

100

$9.97

$997.00

40,560

-15.25%

P

2012-04-25

2012-04-27 09:24:18

director officer (CEO)

15

$10.25

$153.75

40,460

-17.56%

P

2012-04-25

2012-04-27 09:24:18

CEO

133

$10.25

$1,363.25

40,445

-17.56%

S

2012-04-02

2012-04-03 11:55:41

officer (Senior VP Medical Affairs)

1,000

$9.85

$9,852.00

38,383

-6.37%

P

2012-03-28

2012-03-29 15:12:49

CEO

140

$10.19

$1,426.60

40,312

9.72%

P

2012-03-28

2012-03-29 15:12:49

CEO

100

$10.00

$1,000.00

40,172

11.80%

P

2012-03-28

2012-03-29 15:12:49

CEO

103

$10.18

$1,048.54

40,072

9.82%

S

2012-03-01

2012-03-02 16:30:15

officer (Senior VP Medical Affairs)

1,000

$9.82

$9,817.00

38,383

-0.85%

S

2012-02-23

2012-02-27 17:53:45

director

1,250

$10.00

$12,500.00

46,185

5.00%

P

2012-02-22

2012-02-23 09:29:15

director officer (CEO)

1

$9.54

39,969

-1.36%

P

2012-02-22

2012-02-23 09:29:15

CEO

100

$9.45

$945.00

39,968

-0.42%

P

2012-02-22

2012-02-23 09:29:15

director officer (CEO)

2

$9.42

$18.84

39,868

-0.11%

P

2012-02-22

2012-02-23 09:29:15

CEO

100

$9.40

$940.00

39,866

0.11%

P

2012-02-22

2012-02-23 09:29:15

CEO

166

$9.40

$1,560.40

39,766

0.11%

S

2012-02-03

2012-02-03 17:49:39

BRINER KURT W

director

33,000

$10.22

$337,227.00

0

8.21%

S

2012-02-01

2012-02-02 10:49:30

officer (Senior VP Medical Affairs)

1,000

$9.48

$9,478.00

38,383

-3.50%

P

2012-01-25

2012-01-26 10:05:57

CEO

100

$9.56

$956.00

39,600

5.13%

P

2012-01-25

2012-01-26 10:05:57

CEO

193

$9.55

$1,843.15

39,500

5.24%

P

2012-01-25

2012-01-26 10:05:57

director officer (CEO)

4

$9.50

$38.00

39,307

5.79%

P

2012-01-25

2012-01-26 10:05:57

director officer (CEO)

3

$9.49

$28.47

39,303

5.90%

P

2012-01-25

2012-01-26 10:05:57

director officer (CEO)

1

$9.45

39,300

6.35%

P

2012-01-25

2012-01-26 10:05:57

director officer (CEO)

63

$9.45

$595.35

39,299

6.35%

P

2012-01-11

2012-01-12 13:17:06

CEO

200

$8.87

$1,774.00

39,236

7.22%

P

2012-01-11

2012-01-12 13:17:06

CEO

191

$8.86

$1,692.26

39,036

7.34%

P

2011-10-26

2012-01-12 13:17:06

director officer (CEO)

76

$6.50

$494.00

38,211

-22.62%

P

2011-10-26

2012-01-12 13:17:06

CEO

455

$6.52

$2,966.60

38,135

-22.85%

P

2011-10-26

2012-01-12 13:17:06

director officer (CEO)

1

$6.53

37,680

-22.97%

S

2012-01-03

2012-01-04 13:25:26

officer (Senior VP Medical Affairs)

1,000

$8.78

$8,780.00

38,383

-14.24%

S

2011-12-01

2011-12-02 14:57:48

officer (Senior VP Medical Affairs)

1,000

$6.66

$6,660.00

38,383

-28.23%

S

2011-11-23

2011-11-28 14:21:30

director officer (CEO)

634

$5.45

$3,455.30

38,313

-61.83%

S

2011-11-01

2011-11-01 17:25:29

officer (Senior VP Medical Affairs)

1,000

$6.33

$6,330.00

38,383

-10.58%

S

2011-10-05

2011-10-05 17:16:53

officer (Senior VP Medical Affairs)

1,000

$6.33

$6,330.00

38,383

2.37%

P

2011-09-28

2011-09-28 16:56:33

director officer (CEO)

15

$6.38

$95.70

37,029

8.78%

P

2011-09-28

2011-09-28 16:56:33

CEO

527

$6.39

$3,367.53

37,014

8.61%

S

2011-09-27

2011-09-28 09:50:36

officer (Senior VP Medical Affairs)

746

$6.33

$4,722.18

37,843

-7.74%

S

2011-09-20

2011-09-21 12:22:52

officer (Senior VP Medical Affairs)

100

$6.33

$633.00

37,843

0.63%

S

2011-09-01

2011-09-06 14:12:30

officer (Senior VP Medical Affairs)

154

$6.33

$974.82

37,843

9.32%

P

2011-08-24

2011-08-25 09:32:33

CEO

571

$6.08

$3,471.68

36,487

-2.63%

S

2011-08-11

2011-08-12 11:35:10

officer (Senior VP Medical Affairs)

1,000

$6.33

$6,330.00

37,843

19.27%

P

2011-07-27

2011-07-28 17:06:47

CEO

567

$6.12

$3,471.74

35,916

-2.99%

S

2011-07-01

2011-07-06 18:57:19

officer (Senior VP Medical Affairs)

1,000

$7.20

$7,205.00

36,151

18.25%

P

2011-06-22

2011-06-24 10:08:05

CEO

490

$7.08

$3,469.20

31,922

-7.20%

S

2011-06-21

2011-06-22 16:55:03

officer (Senior VP Medical Affairs)

7,889

$7.01

$55,341.30

36,151

1.64%

S

2011-06-21

2011-06-22 16:54:21

officer (Senior VP, Research and Develo)

106

$7.11

$753.66

44,974

2.95%

S

2011-06-21

2011-06-22 16:54:21

officer (Senior VP, Research and Develo)

2,766

$7.09

$19,605.40

45,080

2.65%

S

2011-06-17

2011-06-20 11:27:51

officer (Senior VP, CFO)

3,000

$7.50

$22,500.00

42,444

1.73%

S

2011-06-01

2011-06-02 15:09:29

officer (Senior VP Medical Affairs)

1,000

$8.15

$8,153.00

44,040

9.24%

P

2011-05-25

2011-05-26 15:15:54

CEO

486

$7.13

$3,465.18

31,432

-2.81%

S

2011-05-16

2011-05-17 15:26:37

BRINER KURT W

director

5,000

$8.19

$40,925.00

33,000

8.98%

S

2011-05-13

2011-05-17 15:26:37

BRINER KURT W

director

15,000

$8.27

$123,975.00

38,000

15.43%

S

2011-05-02

2011-05-04 15:30:58

officer (Sr. VP, Medical Affairs)

1,000

$7.39

$7,390.00

44,040

-6.77%

P

2011-04-27

2011-04-27 16:06:29

CEO

479

$7.24

$3,467.96

30,946

8.56%

S

2011-04-01

2011-04-05 09:48:46

officer (Sr. VP, Medical Affairs)

1,000

$6.33

$6,330.00

43,377

-17.06%

S

2011-03-29

2011-03-30 16:29:01

officer (Sr. VP, Medical Affairs)

800

$6.33

$5,064.00

43,377

-17.06%

S

2011-03-08

2011-03-09 14:12:32

officer (Sr. VP, Medical Affairs)

200

$6.33

$1,266.00

43,377

-2.53%

S

2011-02-07

2011-02-08 16:33:00

officer (Sr. VP, Medical Affairs)

7,597

$6.33

$48,089.00

43,377

6.32%

S

2011-01-19

2011-01-20 16:16:10

officer (Sr. VP, Medical Affairs)

403

$6.33

$2,550.99

43,377

8.69%

P

2010-12-01

2010-12-01 16:13:40

CEO

5,000

$4.90

$24,500.00

854,057

11.43%

P

2010-11-01

2010-11-02 11:55:27

CEO

5,000

$4.76

$23,800.00

849,057

4.62%

P

2010-10-04

2010-10-04 17:42:05

CEO

5,000

$4.99

$24,950.00

844,057

0.20%

P

2010-09-01

2010-09-02 10:40:30

CEO

5,000

$4.10

$20,500.00

839,057

23.90%

P

2010-08-02

2010-08-02 17:20:13

CEO

5,000

$4.75

$23,750.00

834,057

-8.42%

P

2010-07-16

2010-07-19 15:02:26

director officer (Chief Executive Officer/CSO)

28

$4.98

$139.44

829,057

-8.84%

P

2010-07-16

2010-07-19 15:02:26

CEO

4,972

$4.99

$24,810.30

829,029

-9.02%

S

2010-06-22

2010-06-24 10:24:37

officer (VP, Research & Development)

2,364

$5.80

$13,723.00

35,494

26.79%

S

2010-06-22

2010-06-24 10:23:49

officer (Sr. VP, Medical Affairs)

6,180

$5.82

$35,961.40

31,186

26.96%

S

2010-06-22

2010-06-24 10:22:45

officer (Sr. VP, Product Dev.)

2,409

$5.74

$13,818.00

36,625

25.91%

S

2010-06-22

2010-06-24 10:21:26

director officer (President)

2,328

$5.66

$13,185.80

26,689

24.96%

S

2010-06-18

2010-06-21 17:19:49

officer (Chief Financial Officer)

4,000

$6.25

$25,000.00

32,925

25.44%

P

2010-06-01

2010-06-02 14:48:48

CEO

5,000

$4.99

$24,950.00

824,057

7.21%

P

2010-05-20

2010-05-21 13:30:05

CEO

4,495

$4.93

$22,160.30

819,057

22.92%

P

2010-05-20

2010-05-21 13:30:05

CEO

505

$4.89

$2,469.45

814,562

23.93%

S

2010-03-18

2010-03-18 15:55:38

officer (Sr. VP, Medical Affairs)

7,056

$5.37

$37,890.70

36,842

-4.28%

S

2010-03-18

2010-03-18 15:54:30

director officer (President)

2,165

$5.33

$11,539.50

28,423

-5.07%

P

2009-10-16

2009-10-19 10:59:53

CEO

18,500

$4.88

$90,243.00

804,942

-14.51%

S

2009-06-23

2009-06-24 17:19:00

officer (VP, Research & Development)

2,500

$4.73

$11,815.00

35,677

-11.09%

S

2009-06-23

2009-06-24 17:16:19

officer (Sr. VP, Product Dev.)

2,000

$4.73

$9,468.00

36,699

-10.90%

S

2009-06-19

2009-06-22 15:07:43

officer (Chief Financial Officer)

5,000

$5.25

$26,265.00

34,590

4.25%

S

2008-10-23

2008-10-24 16:40:33

director

27,000

$9.05

$244,458.00

125,600

15.18%

S

2008-10-22

2008-10-24 16:40:33

director

35,500

$9.39

$333,168.00

152,600

18.17%

S

2008-09-03

2008-09-04 10:27:09

officer (Sr. VP, Medical Affairs)

1,000

$15.00

$15,000.00

39,801

14.33%

S

2008-08-01

2008-08-05 10:08:38

officer (Sr. VP, Medical Affairs)

1,000

$16.47

$16,465.00

39,801

16.55%

S

2008-07-15

2008-07-17 14:07:45

director

2,500

$16.03

$40,087.50

188,000

16.56%

S

2008-07-15

2008-07-17 14:07:45

director

2,500

$16.03

$40,087.50

188,000

16.56%

S

2008-07-15

2008-07-17 14:07:45

director

2,500

$16.03

$40,087.50

188,000

16.56%

S

2008-07-15

2008-07-17 14:07:45

director

2,500

$16.03

$40,087.50

188,000

16.56%

S

2008-07-01

2008-07-03 13:28:46

officer (Sr. VP, Medical Affairs)

1,000

$15.59

$15,592.00

33,134

-7.75%

S

2008-06-02

2008-06-02 16:29:20

officer (Sr. VP, Medical Affairs)

1,000

$16.40

$16,397.00

36,291

7.67%

S

2008-05-27

2008-05-28 14:16:42

officer (Sr. VP, Medical Affairs)

1,000

$15.00

$15,000.00

36,291

-9.20%

S

2008-04-25

2008-04-28 15:22:17

officer (Sr. VP, Medical Affairs)

1,000

$15.00

$15,000.00

36,291

5.67%

S

2008-03-03

2008-03-04 15:49:19

officer (Sr. VP, Medical Affairs)

1,000

$15.30

$15,300.00

35,879

51.50%

S

2008-02-01

2008-02-04 14:56:28

officer (Sr. VP, Medical Affairs)

1,000

$16.44

$16,440.00

35,879

6.93%

S

2008-01-02

2008-01-04 15:40:09

officer (Sr. VP, Medical Affairs)

1,000

$18.12

$18,120.00

35,879

5.30%

S

2007-12-06

2007-12-10 14:30:13

officer (Sr. VP, Medical Affairs)

1,000

$20.00

$20,000.00

35,730

18.55%

S

2007-12-03

2007-12-05 17:31:13

officer (VP, Research & Development)

4,000

$19.03

$76,112.00

32,756

8.19%

S

2007-12-03

2007-12-05 16:32:50

officer (Sr. VP, Medical Affairs)

1,000

$19.24

$19,239.00

35,730

9.19%

S

2007-10-15

2007-10-17 10:58:14

officer 10% owner (Chief Executive Officer/CSO)

15,000

$23.49

$352,380.00

695,148

9.93%

S

2007-10-01

2007-10-03 16:49:55

officer 10% owner (Chief Executive Officer/CSO)

12,000

$22.03

$264,312.00

694,969

-2.92%

S

2007-09-17

2007-09-19 10:20:23

officer 10% owner (Chief Executive Officer/CSO)

12,000

$23.39

$280,728.00

694,969

-1.31%

S

2007-09-04

2007-09-06 10:56:36

officer 10% owner (Chief Executive Officer/CSO)

12,000

$23.76

$285,180.00

694,969

6.92%

S

2007-08-15

2007-08-16 16:31:22

officer (Sr. VP, Product Dev.)

500

$22.85

$11,425.00

36,209

-4.73%

S

2007-08-15

2007-08-16 16:31:22

officer (Sr. VP, Product Dev.)

1,500

$22.92

$34,374.00

36,209

-4.42%

S

2007-08-15

2007-08-16 16:28:26

officer 10% owner (Chief Executive Officer/CSO)

12,000

$23.16

$277,860.00

694,969

-3.35%

S

2007-08-01

2007-08-02 18:22:57

officer 10% owner (Chief Executive Officer/CSO)

12,000

$21.23

$254,784.00

694,969

-8.66%

S

2007-07-16

2007-07-18 15:44:11

officer (Sr. VP, Product Dev.)

500

$21.36

$10,680.00

36,209

-11.99%

S

2007-07-16

2007-07-18 15:44:11

officer (Sr. VP, Product Dev.)

1,500

$21.66

$32,488.50

36,209

-10.44%

S

2007-07-16

2007-07-18 15:41:39

officer 10% owner (Chief Executive Officer/CSO)

12,000

$21.46

$257,472.00

694,969

-11.48%

S

2007-07-02

2007-07-05 16:24:53

officer 10% owner (Chief Executive Officer/CSO)

12,000

$21.68

$260,112.00

694,969

2.93%

S

2007-06-15

2007-06-18 16:35:45

officer (Sr. VP, Product Dev.)

500

$22.04

$11,020.00

28,926

0.36%

S

2007-06-15

2007-06-18 16:35:45

officer (Sr. VP, Product Dev.)

1,500

$22.01

$33,022.50

28,926

0.25%

S

2007-06-01

2007-06-04 17:02:18

officer 10% owner (Chief Executive Officer/CSO)

12,000

$21.75

$261,012.00

657,290

0.83%

S

2007-05-15

2007-05-16 17:29:54

officer (Sr. VP, Product Dev.)

500

$21.90

$10,948.00

28,926

-0.25%

S

2007-05-15

2007-05-16 17:29:54

officer (Sr. VP, Product Dev.)

1,500

$21.91

$32,863.50

28,926

-0.19%

S

2007-05-15

2007-05-16 17:26:34

officer 10% owner (Chief Executive Officer/CSO)

12,000

$21.90

$262,800.00

657,290

-0.23%

S

2007-05-01

2007-05-03 15:41:56

officer 10% owner (Chief Executive Officer/CSO)

12,000

$25.61

$307,356.00

657,290

-0.50%

S

2007-04-16

2007-04-18 13:25:39

officer (Sr. VP, Product Dev.)

500

$27.06

$13,530.00

28,926

18.88%

S

2007-04-16

2007-04-18 13:25:39

officer (Sr. VP, Product Dev.)

1,500

$26.81

$40,221.00

28,926

18.14%

S

2007-04-16

2007-04-17 18:12:59

officer 10% owner (Chief Executive Officer/CSO)

12,000

$26.80

$321,588.00

657,290

18.09%

S

2007-04-02

2007-04-04 15:18:00

officer 10% owner (Chief Executive Officer/CSO)

12,000

$23.85

$286,152.00

657,117

-4.34%

S

2007-03-15

2007-03-19 13:52:01

officer (Sr. VP, Product Dev.)

500

$22.77

$11,385.00

33,676

-18.45%

S

2007-03-15

2007-03-19 13:52:01

officer (Sr. VP, Product Dev.)

1,500

$22.80

$34,197.00

33,676

-18.30%

S

2007-03-15

2007-03-19 13:51:09

officer 10% owner (Chief Executive Officer/CSO)

12,000

$22.95

$275,424.00

657,117

-17.51%

S

2007-03-01

2007-03-02 15:30:25

officer 10% owner (Chief Executive Officer/CSO)

12,000

$26.49

$317,832.00

657,117

10.59%

S

2007-03-01

2007-03-02 15:28:01

director

10,000

$25.99

$259,890.00

32,181

8.88%

S

2007-02-15

2007-02-28 15:12:55

officer (Sr. VP, Product Dev.)

1,000

$30.08

$30,080.00

33,676

21.01%

S

2007-02-15

2007-02-28 15:12:55

officer (Sr. VP, Product Dev.)

3,000

$29.94

$89,816.10

33,676

20.64%

S

2007-02-15

2007-02-22 12:46:01

officer (Sr. VP, Product Dev.)

1,000

$30.08

$30,080.00

33,676

21.01%

S

2007-02-15

2007-02-22 12:46:01

officer (Sr. VP, Product Dev.)

3,000

$29.94

$89,816.10

33,676

20.64%

S

2007-02-15

2007-02-20 15:06:37

officer (Sr. VP, Product Dev.)

4,000

$29.97

$119,896.00

33,676

20.73%

S

2007-02-15

2007-02-20 10:47:35

officer 10% owner (Chief Executive Officer/CSO)

12,000

$29.89

$358,716.00

641,160

20.52%

S

2007-02-12

2007-02-14 13:12:27

officer (Chief Financial Officer)

4,000

$29.48

$117,908.00

22,694

20.58%

S

2007-02-02

2007-02-06 14:28:26

director

5,000

$30.05

$150,250.00

32,181

15.77%

S

2007-02-02

2007-02-06 14:28:26

director

5,000

$30.08

$150,400.00

32,181

15.86%

S

2007-02-02

2007-02-06 14:28:26

director

10,000

$30.10

$301,000.00

32,181

15.91%

S

2007-02-02

2007-02-06 14:28:26

director

10,000

$30.15

$301,500.00

32,181

16.05%

S

2007-02-01

2007-02-02 16:54:30

officer 10% owner (Chief Executive Officer/CSO)

12,000

$29.89

$358,632.00

641,160

12.63%

S

2007-01-29

2007-01-31 15:28:46

BAKER CHARLES A

director

2,500

$30.02

$75,050.00

21,481

7.56%

S

2007-01-29

2007-01-31 15:25:51

officer (Chief Financial Officer)

4,000

$29.72

$118,872.00

22,694

6.62%

S

2007-01-16

2007-01-18 16:07:39

officer (Chief Financial Officer)

4,000

$28.79

$115,160.00

22,694

-3.58%

S

2007-01-16

2007-01-18 16:03:26

officer 10% owner (Chief Executive Officer/CSO)

12,000

$28.58

$342,912.00

641,160

-4.35%

S

2007-01-03

2007-01-05 15:25:05

officer (Chief Financial Officer)

4,000

$25.68

$102,708.00

22,597

-17.38%

S

2007-01-03

2007-01-05 15:13:49

officer 10% owner (Chief Executive Officer/CSO)

12,000

$25.68

$308,124.00

640,987

-17.38%

S

2006-12-15

2006-12-22 16:09:32

officer (Sr. VP, Product Dev.)

500

$26.05

$13,025.00

33,579

-9.83%

S

2006-12-15

2006-12-19 16:12:09

officer (Sr. VP, Product Dev.)

500

$26.05

$13,025.00

33,579

-9.83%

S

2006-12-15

2006-12-19 16:12:09

officer (Sr. VP, Product Dev.)

1,500

$26.05

$39,075.00

33,579

-9.83%

S

2006-12-15

2006-12-19 16:08:15

officer 10% owner (Chief Executive Officer/CSO)

12,000

$26.14

$313,668.00

640,987

-9.45%

S

2006-12-11

2006-12-12 15:56:05

officer (Chief Financial Officer)

4,000

$27.75

$110,988.00

22,597

-1.88%

S

2006-12-04

2006-12-06 15:35:22

officer (Sr. VP, Medical Affairs)

5,000

$28.00

$140,000.00

26,690

3.36%

S

2006-12-01

2006-12-05 16:26:07

officer (Sr. VP, Medical Affairs)

5,000

$26.91

$134,565.00

26,690

4.36%

S

2006-12-01

2006-12-05 16:20:43

officer 10% owner (Chief Executive Officer/CSO)

5,000

$26.91

$134,565.00

640,987

4.36%

S

2006-12-01

2006-12-05 16:20:43

officer 10% owner (Chief Executive Officer/CSO)

7,000

$26.75

$187,278.00

640,987

3.79%

S

2006-12-01

2006-12-05 15:29:10

director

5,000

$27.15

$135,735.00

24,181

5.18%

S

2006-12-01

2006-12-05 15:29:10

director

3,000

$27.15

$81,450.00

24,181

5.19%

S

2006-12-01

2006-12-05 15:29:10

director

2,000

$27.15

$54,302.00

24,181

5.20%

S

2006-11-27

2006-11-29 15:43:47

officer (Chief Financial Officer)

4,000

$28.05

$112,188.00

22,597

6.94%

S

2006-11-15

2006-11-17 17:01:28

officer (Sr. VP, Product Dev.)

1,500

$28.93

$43,402.50

33,579

9.21%

S

2006-11-15

2006-11-17 17:01:28

officer (Sr. VP, Product Dev.)

500

$28.92

$14,461.00

33,579

9.17%

S

2006-11-15

2006-11-17 16:22:18

officer 10% owner (Chief Executive Officer/CSO)

5,000

$29.26

$146,290.00

640,987

10.21%

S

2006-11-15

2006-11-17 16:22:18

officer 10% owner (Chief Executive Officer/CSO)

7,000

$29.07

$203,462.00

640,987

9.62%

S

2006-11-13

2006-11-14 13:13:57

officer (Chief Financial Officer)

4,000

$29.03

$116,124.00

22,597

9.27%

S

2006-11-10

2006-11-14 13:13:57

officer (Chief Financial Officer)

4,000

$28.00

$112,000.00

22,597

0.68%

S

2006-11-10

2006-11-14 13:12:11

officer (Sr. VP, Medical Affairs)

5,000

$28.00

$140,000.00

26,690

0.68%

S

2006-11-01

2006-11-02 13:34:52

officer (Chief Financial Officer)

4,000

$25.96

$103,856.00

22,597

-7.23%

S

2006-11-01

2006-11-02 13:26:18

officer (Sr. VP, Medical Affairs)

5,000

$25.96

$129,820.00

26,690

-7.23%

S

2006-11-01

2006-11-02 13:25:46

officer 10% owner (Chief Executive Officer/CSO)

12,000

$25.96

$311,568.00

640,987

-7.23%

S

2006-10-27

2006-10-27 16:38:49

officer (Chief Financial Officer)

4,000

$26.00

$104,000.00

22,597

-6.38%

S

2006-10-16

2006-10-17 15:13:24

officer 10% owner (Chief Executive Officer/CSO)

12,000

$24.00

$288,000.00

640,987

-21.17%

S

2006-10-02

2006-10-04 10:41:12

officer (Sr. VP, Medical Affairs)

5,000

$23.37

$116,865.00

26,690

-7.13%

S

2006-10-02

2006-10-04 10:36:11

officer 10% owner (Chief Executive Officer/CSO)

12,000

$23.37

$280,476.00

640,987

-7.13%

S

2006-09-15

2006-09-19 16:03:28

officer 10% owner (Chief Executive Officer/CSO)

5,000

$24.23

$121,160.00

640,828

1.37%

S

2006-09-15

2006-09-19 16:03:28

officer 10% owner (Chief Executive Officer/CSO)

2,000

$23.86

$47,730.00

640,828

-0.15%

S

2006-09-15

2006-09-19 16:03:28

officer 10% owner (Chief Executive Officer/CSO)

2,000

$23.74

$47,480.00

640,828

-0.67%

S

2006-09-15

2006-09-19 16:03:28

officer 10% owner (Chief Executive Officer/CSO)

3,000

$23.66

$70,980.00

640,828

-1.01%

S

2006-09-01

2006-09-06 12:56:06

officer (Sr. VP, Medical Affairs)

5,000

$22.72

$113,600.00

26,579

-3.26%

S

2006-09-01

2006-09-06 12:50:11

officer 10% owner (Chief Executive Officer/CSO)

12,000

$22.72

$272,640.00

640,828

-3.26%

S

2006-08-15

2006-08-16 15:20:57

officer 10% owner (Chief Executive Officer/CSO)

12,000

$20.20

$242,412.00

640,828

-17.62%

S

2006-08-01

2006-08-03 16:16:42

officer (Sr. VP, Medical Affairs)

5,000

$21.60

$108,000.00

26,579

-4.91%

S

2006-08-01

2006-08-03 16:12:16

officer 10% owner (Chief Executive Officer/CSO)

7,000

$21.60

$151,200.00

640,828

-4.91%

S

2006-08-01

2006-08-03 16:12:16

officer 10% owner (Chief Executive Officer/CSO)

5,000

$21.54

$107,700.00

640,828

-5.20%

S

2006-07-17

2006-07-19 14:34:12

officer 10% owner (Chief Executive Officer/CSO)

12,000

$21.10

$253,224.00

640,828

-4.16%

S

2006-07-03

2006-07-06 17:21:47

officer (Sr. VP, Medical Affairs)

5,000

$23.84

$119,185.00

19,822

7.20%

S

2006-07-03

2006-07-06 17:19:34

officer 10% owner (Chief Executive Officer/CSO)

2,000

$23.84

$47,674.00

592,492

7.20%

S

2006-07-03

2006-07-06 17:19:34

officer 10% owner (Chief Executive Officer/CSO)

10,000

$23.84

$238,370.00

592,492

7.20%

S

2006-06-21

2006-06-26 11:23:17

Kremer Alton B

officer (VP, Clinical Research)

875

$21.60

$18,900.00

6,187

3.10%

S

2006-06-21

2006-06-23 11:31:16

officer 10% owner (Chief Executive Officer/CSO)

12,500

$21.62

$270,262.00

592,329

3.20%

S

2006-06-21

2006-06-23 11:30:39

officer (Sr. VP, Medical Affairs)

900

$21.60

$19,440.00

19,822

3.10%

S

2006-06-21

2006-06-23 11:30:01

officer (Sr. VP, Product Dev.)

3,750

$21.64

$81,138.80

16,755

3.27%

S

2006-06-20

2006-06-22 17:11:22

officer (VP, Research & Development)

1,000

$21.62

$21,620.00

17,203

0.42%

S

2006-06-20

2006-06-22 17:10:29

officer (Chief Financial Officer)

3,000

$21.41

$64,239.00

14,244

-0.55%

S

2006-06-15

2006-06-16 15:11:08

officer 10% owner (Chief Executive Officer/CSO)

3,774

$22.01

$83,054.40

604,829

2.53%

S

2006-06-15

2006-06-16 15:11:08

officer 10% owner (Chief Executive Officer/CSO)

6,000

$22.00

$132,000.00

604,829

2.50%

S

2006-06-01

2006-06-05 16:28:17

officer (Sr. VP, Medical Affairs)

5,000

$21.84

$109,220.00

20,722

-10.14%

S

2006-06-01

2006-06-05 16:03:52

officer 10% owner (Chief Executive Officer/CSO)

3,000

$21.88

$65,643.00

604,829

-9.96%

S

2006-06-01

2006-06-05 16:03:52

officer 10% owner (Chief Executive Officer/CSO)

7,000

$21.79

$152,509.00

604,829

-10.43%

S

2006-05-15

2006-05-17 15:20:53

officer 10% owner (Chief Executive Officer/CSO)

10,000

$20.91

$209,090.00

604,829

-8.28%

S

2006-05-05

2006-05-08 12:32:39

officer (VP, Research & Development)

3,893

$24.00

$93,432.00

18,203

9.00%

S

2006-05-04

2006-05-08 12:32:39

officer (VP, Research & Development)

10,107

$24.00

$242,568.00

18,203

6.08%

S

2006-05-01

2006-05-03 13:52:04

officer 10% owner (Chief Executive Officer/CSO)

10,000

$23.52

$235,200.00

604,829

4.93%

S

2006-05-01

2006-05-02 14:13:23

officer (Sr. VP, Medical Affairs)

5,000

$23.51

$117,550.00

20,722

4.89%

S

2006-04-17

2006-04-18 17:17:18

officer 10% owner (Chief Executive Officer/CSO)

2,500

$25.47

$63,675.00

604,829

17.12%

S

2006-04-17

2006-04-18 17:17:18

officer 10% owner (Chief Executive Officer/CSO)

2,500

$24.90

$62,250.00

604,829

15.22%

S

2006-04-17

2006-04-18 17:17:18

officer 10% owner (Chief Executive Officer/CSO)

2,500

$24.86

$62,150.00

604,829

15.08%

S

2006-04-17

2006-04-18 17:17:18

officer 10% owner (Chief Executive Officer/CSO)

2,500

$24.78

$61,950.00

604,829

14.81%

S

2006-04-03

2006-04-05 16:45:24

officer (Sr. VP, Medical Affairs)

5,000

$26.16

$130,780.00

20,722

9.24%

S

2006-04-03

2006-04-05 16:45:01

officer 10% owner (Chief Executive Officer/CSO)

2,500

$26.30

$65,750.00

604,829

9.73%

S

2006-04-03

2006-04-05 16:45:01

officer 10% owner (Chief Executive Officer/CSO)

2,500

$26.06

$65,150.00

604,829

8.90%

S

2006-04-03

2006-04-05 16:45:01

officer 10% owner (Chief Executive Officer/CSO)

2,500

$25.58

$63,945.00

604,829

7.19%

S

2006-04-03

2006-04-05 16:45:01

officer 10% owner (Chief Executive Officer/CSO)

2,500

$25.52

$63,797.50

604,829

6.97%

S

2006-03-20

2006-03-21 16:01:11

officer (VP, Research & Development)

2,000

$27.46

$54,920.00

18,135

6.74%

S

2006-03-15

2006-03-17 14:56:11

officer 10% owner (Chief Executive Officer/CSO)

10,000

$27.00

$270,040.00

604,695

5.87%

S

2006-02-27

2006-03-07 15:35:57

director

5,000

$30.02

$150,100.00

24,181

8.49%

S

2006-03-01

2006-03-03 11:45:45

officer 10% owner (Chief Executive Officer/CSO)

10,000

$29.02

$290,210.00

586,615

8.72%

S

2006-03-01

2006-03-02 11:58:12

officer (Sr. VP, Medical Affairs)

10,000

$29.02

$290,210.00

20,628

8.72%

S

2006-02-27

2006-03-01 17:14:11

officer (Chief Financial Officer)

1,500

$30.00

$45,000.00

17,170

8.43%

S

2006-02-21

2006-02-23 16:19:45

officer (VP, Research & Development)

2,000

$28.01

$56,020.00

18,135

3.32%

S

2006-02-15

2006-02-17 11:28:44

officer 10% owner (Chief Executive Officer/CSO)

10,000

$27.17

$271,680.00

586,615

-1.55%

S

2006-02-15

2006-02-17 11:25:28

officer (Sr. VP, Medical Affairs)

1,858

$28.00

$52,024.00

20,628

1.46%

S

2006-02-15

2006-02-17 11:22:43

officer (Sr. VP, Product Dev.)

10,000

$28.00

$280,000.00

20,430

1.46%

S

2006-02-01

2006-02-03 16:38:10

officer (Sr. VP, Medical Affairs)

5,000

$27.73

$138,670.00

20,628

-5.86%

S

2006-02-01

2006-02-03 16:38:10

officer (Sr. VP, Medical Affairs)

3,142

$28.00

$87,976.00

20,628

-4.86%

S

2006-02-01

2006-02-03 16:18:15

officer 10% owner (Chief Executive Officer/CSO)

10,000

$27.73

$277,270.00

586,615

-5.89%

S

2006-01-30

2006-02-01 16:08:19

Kremer Alton B

officer (VP, Clinical Research)

8,000

$27.63

$221,064.00

6,966

-6.76%

S

2005-12-19

2005-12-20 16:25:03

officer (Sr. VP, Medical Affairs)

8,750

$22.38

$195,842.00

20,496

-27.65%

S

2005-09-13

2005-09-14 09:39:57

officer (Sr. VP, Medical Affairs)

3,000

$25.00

$75,000.00

20,155

12.88%

S

2005-09-12

2005-09-14 09:39:57

officer (Sr. VP, Medical Affairs)

2,000

$25.00

$50,000.00

23,155

16.40%

S

2005-08-01

2005-08-03 19:44:21

officer (Chief Financial Officer)

2,000

$23.35

$46,700.00

18,284

-3.64%

S

2005-08-01

2005-08-03 19:44:21

officer (Chief Financial Officer)

4,000

$23.40

$93,600.00

18,284

-3.42%

S

2005-08-01

2005-08-03 19:44:21

officer (Chief Financial Officer)

4,000

$23.45

$93,800.00

18,284

-3.20%

S

2005-08-01

2005-08-03 19:44:21

officer (Chief Financial Officer)

2,000

$23.50

$47,000.00

18,284

-2.98%

S

2005-07-01

2005-07-06 21:51:49

director

2,000

$20.85

$41,700.00

23,713

-12.52%

S

2005-06-20

2005-06-22 16:42:22

officer (SR. VP, Product Development)

750

$19.85

$14,887.50

12,426

-14.36%

S

2005-06-21

2005-06-22 16:41:21

officer (VP, Research and Development)

650

$20.00

$13,000.00

13,111

-14.95%

S

2005-06-21

2005-06-22 16:40:28

director officer (CEO & CSO)

3,250

$20.05

$65,162.50

599,303

-14.66%

S

2005-06-21

2005-06-22 16:40:28

director officer (CEO & CSO)

3,000

$20.00

$60,000.00

602,553

-14.95%

S

2005-06-20

2005-06-22 16:39:41

director other

3,000

$19.85

$59,550.00

188,100

-14.36%

S

2005-06-20

2005-06-22 16:39:09

officer (Cheif Financial Officer)

750

$19.87

$14,902.50

13,625

-14.24%

S

2005-06-20

2005-06-22 16:38:22

GOFF STEPHEN P

director

3,000

$19.85

$59,550.00

33,500

-14.36%

S

2005-06-20

2005-06-22 16:37:48

officer (SR. VP Medical Affairs)

750

$19.87

$14,902.50

21,477

-14.24%

S

2005-02-24

2005-02-28 17:51:13

officer (Vice President, Finance & Oper)

3,000

$24.00

$72,000.00

14,271

24.62%

S

2005-02-07

2005-02-07 17:54:32

director officer (President)

8,000

$21.00

$168,000.00

33,578

6.29%

S

2005-02-04

2005-02-07 17:54:32

director officer (President)

6,000

$21.20

$127,200.00

33,578

4.06%

S

2005-02-04

2005-02-07 17:54:32

director officer (President)

6,000

$21.15

$126,900.00

39,578

3.83%

S

2005-02-04

2005-02-07 17:54:32

director officer (President)

2,000

$21.12

$42,240.00

45,578

3.69%

S

2005-02-04

2005-02-07 17:54:32

director officer (President)

4,000

$21.00

$84,000.00

47,578

3.14%

S

2005-02-02

2005-02-03 20:35:55

director officer (President)

1,000

$20.60

$20,600.00

33,578

-9.81%

S

2005-02-02

2005-02-03 20:35:55

director officer (President)

10,000

$20.50

$205,000.00

34,578

-10.34%

S

2005-02-01

2005-02-03 20:35:55

director officer (President)

1,000

$20.00

$20,000.00

33,578

-13.40%

S

2005-02-01

2005-02-03 20:35:55

director officer (President)

1,000

$20.15

$20,150.00

34,578

-12.56%

S

2005-02-01

2005-02-03 20:35:55

director officer (President)

2,000

$20.10

$40,200.00

35,578

-12.84%

S

2005-02-01

2005-02-03 20:35:55

director officer (President)

1,000

$20.20

$20,200.00

37,578

-12.28%

S

2005-02-01

2005-02-03 20:35:55

director officer (President)

1,000

$20.25

$20,250.00

38,578

-12.00%

S

2005-01-31

2005-02-01 17:39:58

director officer (President)

400

$19.87

$7,948.00

17,778

-16.86%

S

2005-01-31

2005-02-01 17:39:58

director officer (President)

2,000

$20.25

$40,500.00

18,178

-14.67%

S

2005-01-31

2005-02-01 17:39:58

director officer (President)

1,000

$19.50

$19,500.00

20,178

-19.08%

S

2005-01-31

2005-02-01 17:39:58

director officer (President)

1,000

$19.55

$19,550.00

21,178

-18.77%

S

2005-01-31

2005-02-01 17:39:58

director officer (President)

1,000

$19.50

$19,500.00

22,178

-19.08%

S

2005-01-31

2005-02-01 17:39:58

director officer (President)

1,000

$19.55

$19,550.00

23,178

-18.77%

S

2005-01-31

2005-02-01 17:39:58

director officer (President)

1,000

$19.60

$19,600.00

24,178

-18.47%

S

2005-01-31

2005-02-01 17:39:58

director officer (President)

1,000

$19.65

$19,650.00

25,178

-18.17%

S

2005-01-31

2005-02-01 17:39:58

director officer (President)

1,000

$19.70

$19,700.00

26,178

-17.87%

S

2005-01-31

2005-02-01 17:39:58

director officer (President)

600

$19.85

$11,910.00

27,178

-16.98%

S

2005-01-31

2005-02-01 17:39:58

director officer (President)

2,000

$19.90

$39,800.00

27,778

-16.68%

S

2005-01-31

2005-02-01 17:39:58

director officer (President)

2,000

$20.00

$40,000.00

29,778

-16.10%

S

2005-01-31

2005-02-01 17:39:58

director officer (President)

2,000

$20.00

$40,000.00

31,778

-16.10%

S

2005-01-31

2005-02-01 17:39:58

director officer (President)

1,000

$20.10

$20,100.00

33,778

-15.52%

S

2005-01-31

2005-02-01 17:39:58

director officer (President)

2,000

$20.15

$40,300.00

34,778

-15.24%

S

2005-01-31

2005-02-01 17:39:58

director officer (President)

2,000

$20.10

$40,200.00

36,778

-15.52%

S

2005-01-31

2005-02-01 17:39:58

director officer (President)

2,000

$20.20

$40,400.00

38,778

-14.95%

S

2005-01-25

2005-01-25 20:04:36

director officer (President)

2,000

$19.00

$38,000.00

17,778

-24.84%

S

2005-01-24

2005-01-25 20:04:36

director officer (President)

2,000

$19.02

$38,040.00

17,778

-25.87%

S

2005-01-21

2005-01-25 20:04:36

director officer (President)

1,000

$19.00

$19,000.00

17,778

-13.16%

S

2005-01-21

2005-01-25 20:04:36

director officer (President)

1,000

$19.35

$19,350.00

18,778

-11.11%

S

2005-01-21

2005-01-25 20:04:36

director officer (President)

2,000

$19.30

$38,600.00

19,778

-11.40%

S

2005-01-21

2005-01-25 20:04:36

director officer (President)

2,000

$19.25

$38,500.00

21,778

-11.69%

S

2005-01-21

2005-01-25 20:04:36

director officer (President)

3,000

$19.20

$57,600.00

23,778

-11.98%

S

2004-12-22

2004-12-28 10:17:59

officer (Senior Vice President, Medical)

1,300

$16.91

$21,979.00

0

-12.68%

S

2004-12-22

2004-12-28 10:16:59

director

4,000

$17.00

$68,000.00

21,963

-12.06%

S

2004-06-02

2004-06-03 16:54:57

officer (Senior VP, Medical Affairs)

1,000

$16.80

$16,800.00

0

3.27%

S

2004-06-01

2004-06-03 16:54:57

officer (Senior VP, Medical Affairs)

1,000

$17.10

$17,100.00

0

4.09%

S

2004-06-01

2004-06-03 16:54:57

officer (Senior VP, Medical Affairs)

1,000

$17.05

$17,050.00

0

3.81%

S

2004-06-01

2004-06-03 16:54:57

officer (Senior VP, Medical Affairs)

1,000

$17.00

$17,000.00

0

3.53%

S

2004-06-01

2004-06-03 16:54:57

officer (Senior VP, Medical Affairs)

750

$16.83

$12,622.50

0

2.55%