X0303 4 2010-09-02 0 0001333763 Chelsea Therapeutics International, Ltd. CHTP 0001316736 Pedder Simon 3530 TORINGDON WAY SUITE 200 CHARLOTTE NC 28277 1 1 0 0 Chief Executive Officer Common Stock 2010-09-02 4 P 0 1250 4.08 A 488180 D Stock Option (Right to Buy) 2.96 2020-01-19 Common Stock 175000 175000 D Stock Option (Right to Buy) 1.85 2019-05-01 Common Stock 47890 47890 D Stock Option (Right to Buy) 1.78 2019-01-22 Common Stock 175000 175000 D Stock Option (Right to Buy) 6.5 2018-01-24 Common Stock 175000 175000 D Stock Option (Right to Buy) 5.68 2017-02-06 Common Stock 175000 175000 D Stock Option (Right to Buy) 3.9 2016-06-19 Common Stock 167585 167585 D Stock Option (Right to Buy) 3.5 2016-02-01 Common Stock 100000 100000 D Stock Option (Right to Buy) 2.62 2015-01-10 Common Stock 478726 478726 D Option vests in four equal annual installments beginning on January 19, 2011. Option vests in four equal annual installments beginning on May 1, 2010. Option vests in four equal annual installments beginning on January 22, 2010. Option vests in four equal annual installments beginning on January 24, 2009. Option vests in four equal annual installments beginning on February 6, 2008. Option vests in four equal annual installments beginning on June 19, 2007. Option vests in four equal annual installments beginning on February 1, 2007. Option vested in four equal annual installments beginning on January 10, 2006. /s/ Alexander M. Donaldson, Attorney-in-Fact 2010-09-07