X0202 4 2007-11-27 0001382911 Orexigen Therapeutics, Inc. OREX 0001024000 BLAIR JAMES C C/O DOMAIN ASSOCIATES, LLC ONE PALMER SQUARE PRINCETON NJ 08542 0 0 1 0 Common Stock 2007-11-27 4 J 0 900000 D 3543832 I By Domain Partners V, L.P. Common Stock 2007-11-27 4 J 0 1963 A 1963 I By Domain Associates, LLC Common Stock 2007-11-27 4 J 0 19373 A 19373 D Common Stock 2007-11-27 4 S 0 21000 14.27 D 83975 I By DP V Associates, L.P. Distribution of shares from Domain Partners V, L.P. to its partners, and the simultaneous distribution of the portion of such shares received by One Palmer Square Associates V, LLC, its general partner, to its members. The Reporting Person is a Managing Member of Domain Associates, LLC and a Managing Member of One Palmer Square Associates V, L.P., which is the sole general partner of Domain Partners V, L.P. and DP V Associates, L.P. Pursuant to Instruction 4(b)(iv) of Form 4, the Reporting Person has elected to report as indirectly beneficially owned the entire number of securities beneficially owned by each such entity. The Reporting Person disclaims beneficial ownership of any securities, and any proceeds thereof, that exceed his or her pecuniary interest therein and/or that are not actually distributed to him or her. /s/Kathleen K. Schoemaker, Attorney-in-Fact 2007-11-27