X0202 4 2006-02-27 0001178670 ALNYLAM PHARMACEUTICALS, INC. ALNY 0001291895 Barrett Peter C/O ATLAS VENTURE SUITE 320 890 WINTER STREET WALTHAM MA 02451 1 0 0 0 Common Stock 2006-02-27 4 S 0 79047 15.7719 D 0 I See Footnote Common Stock 2006-02-28 4 S 0 28947 15.9842 D 285962 I See Footnote Common Stock 2006-02-27 4 S 0 19638 15.7719 D 0 I See Footnote Common Stock 2006-02-28 4 S 0 7191 15.9842 D 71042 I See Footnote Common Stock 2006-02-27 4 S 0 1316 15.7719 D 0 I See Footnote Common Stock 2006-02-28 4 S 0 482 15.9842 D 4759 I See Footnote Common Stock 2006-02-27 4 S 0 143497 15.7719 D 0 I See Footnote Common Stock 2006-02-28 4 S 0 52548 15.9842 D 519126 I See Footnote Common Stock 2006-02-27 4 S 0 3875 15.7719 D 0 I See Footnote Common Stock 2006-02-28 4 S 0 1419 15.9842 D 14020 I See Footnote Common Stock 2006-02-27 4 S 0 2627 15.7719 D 0 I See Footnote Common Stock 2006-02-28 4 S 0 962 15.9842 D 9506 I See Footnote Sale of shares of the Issuer's Common Stock by Atlas Venture Fund V, L.P. ("Atlas V"). These shares are owned directly by Atlas V. Peter Barrett is a Senior Partner of Atlas Venture. Mr. Barrett disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein. Sale of shares of the Issuer's Common Stock by Atlas Venture Parallel Fund V-A, C.V. ("Atlas V-A"). These shares are owned directly by Atlas V-A. Peter Barrett is a Senior Partner of Atlas Venture. Mr. Barrett disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein. Sale of shares of the Issuer's Common Stock by Atlas Venture Entrepreneurs' Fund V, L.P. ("AVE V"). These shares are owned directly by AVE V. Peter Barrett is a Senior Partner of Atlas Venture. Mr. Barrett disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein. Sale of shares of the Issuer's Common Stock by Atlas Venture Fund VI, L.P. ("Atlas VI"). These shares are owned directly by Atlas VI. Peter Barrett is a Senior Partner of Atlas Venture. Mr. Barrett disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein. Sale of shares of the Issuer's Common Stock by Atlas Venture Entrepreneurs' Fund VI, L.P. ("AVE VI"). These shares are owned directly by AVE VI. Peter Barrett is a Senior Partner of Atlas Venture. Mr. Barrett disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein. Sale of shares of the Issuer's Common Stock by Atlas Venture Fund VI GmbH & Co. KG. ("AV VI KG"). These shares are owned directly by AV VI KG. Peter Barrett is a Senior Partner of Atlas Venture. Mr. Barrett disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein. /s/ Jeanne Larkin Henry - Attorney in Fact 2006-03-01